The Church of the Nazarene is the largest denomination in the classical Wesleyan-Holiness tradition. The doctrine that distinguishes the Church of the Nazarene and other Wesleyan denominations from most other Christian denominations is that of entire sanctification. Nazarenes believe that God calls Christians to a life of holy living that is marked by an act of God, cleansing the heart from original sin and filling the individual with love for God and humankind.